Drug resistant malaria on Thailand-Burma border grows by 3,335%

Two recent studies of malaria along the Thailand-Burma border show that drug-resistant malaria in the region is increasing at an alarming rate, with one study showing a 3,335 percent increase in the last 10 years.

The reports, Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study published in The Lancet and A Major Genome Region Underlying Artemisinin Resistance in Malaria, published in the journal Science, show drug-resistant malaria is rapidly moving into new areas

Funded by the Wellcome Trust and the US National Institutes of Health, the two research projects included scientists from Bangkok’s Mahidol University, the Centre for Tropical Medicine at Britain’s Oxford University, and the Texas Biomedical Research Institute in the USA, found that 42 percent of malaria cases in western Cambodia were resistant to drug treatment, indicating that drug resistant malaria along the Thailand-Burma border is rapidly approaching the rate in Cambodia.

A female Anopheles albimanus mosquito feeding on a human host.
A female Anopheles albimanus mosquito feeding on a human host Photo: James Gathany/USCDC

Researchers said malaria that was resistant to the current standard drug therapy, artemisinin, had spread more than 800km (500 miles) west to the Thailand-Burma border since it was confirmed in Cambodia in 2006, with a study of 3,202 people who contracted malaria in the region between 2001 and 2010 finding a steady increase in the time it took for the disease to be eliminated from their body – from 0.6 percent of cases in 2007 to 20 percent in 2010.

According to The Lancet, the speed with which drug-resistant malaria is growing along the Thailand-Burma border means drug-resistant malaria will reach rates equivalent to those reported in western Cambodia in between two to six years.

Of concern is a finding in the report published in Science, where researchers identified a region of the Plasmodium falciparum (P. falciparum) parasite’s genome that may be mutating in order to survive.

The study compared the genomes of 91 P. falciparum parasites from Cambodia and western Thailand with those from Laos, where drug resistant malaria has so far not emerged, and found seven genes that may be responsible for the parasites resistance to malaria treatment drugs, and which may explain the up to 35 percent malaria drug resistance that is occurring in Southeast Asia.

Thailand-Burma border malaria resistant to our best drugs

Francois Nosten: "We have now seen the emergence of malaria resistant to our best drugs".
Francois Nosten: “We have now seen the emergence of malaria resistant to our best drugs”. Photo: Courtesy SMRU

Leader of the study, Francois Nosten, director of the Shoklo Malaria Research Unit who studies and treats malaria in the Thailand-Burma border region said, “we have now seen the emergence of malaria resistant to our best drugs, and these resistant parasites are not confined to western Cambodia”.

Mr Nosten said, this is very worrying and suggests we are in a race against time to control malaria in this region before P. falciparum drug resistance worsens, develops, and spreads further.

Though the number of deaths in Africa from malaria have been decreasing in recent years due to increased artemisinin drug use and wider distribution of insecticide-treated bed nets, the World Health Organization (WHO) says an estimated 655,000 people died from the disease in 2010, though a 2010 report by the Institute of Health Metrics and Evaluation at the University of Washington, Seattle put the figure at up to 1.2 million people.

If resistance to artemisinin drug regimes continues to spread some specialists fear Africa could see a resurgence in drug-resistant malaria and a reversal of the inroads made in combating the debilitating and deadly disease.

While residents of malaria endemic areas are well educated in the risk, precautions and symptoms, this does not apply equally so travelers and the UKs Health Protection Agency (HPA) reported last year an almost 30 percent increase in the number of Britons contracting malaria in 2009 and 2010.

Rapid malaria tests for travelers

Home Kit Biotech's rapid medical test kits for travelers comprises a malaria instant test kit and a dengue instant test kit for under $26.
Home Kit Biotech’s rapid medical test kits for travelers comprises a malaria instant test kit and a dengue instant test kit for under $26. Photo: Home Kit Biotech

According to the HPA report, of the 1,761 confirmed cases in 2010 and 1,495 cases reported in 2009, almost 40 percent of Britons who contracted malaria had visited Nigeria or Ghana, while 11 percent had been to India.

Home Kit Biotech (HKB) is an internet-based business that sells a range of instant blood screening instant test kits, including rapid instant test kits for malaria and dengue fever.

Pam Johnson, HKB customer service manager, said there was a steady demand for the company’s rapid medical test kits for travelers, which comprises a rapid Malaria instant test kit and a rapid Dengue instant test kit.

“People are increasingly traveling to and spending longer periods of of time in malaria infected areas for work, as tourists, or volunteers and often there are language problems or the nearest reliable medical testing facility is hundreds of kilometers or more away .

“Our rapid medical test kits for travelers are proven to be able to detect 99.6 percent of all positive cases (sensitivity) and 99.7% accurate at returning false positives (specificity), which means for less than $26 (¬£19.85) people can test them self and provided they follow the instructions, receive a pretty accurate diagnosis of whether they are infected with malaria or not”.

Ms Johnson said that HKB will soon be adding a rapid chikungunya instant test to it’s rapid medical test kits for travelers, with increasing reports of outbreaks in Cambodia, China and India in particular.

ENDS:
© 2012 John Le Fevre

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Drug resistant malaria, Thailand-Burma border, malaria instant test kits, dengue instant test kit, rapid medical test kits for travelers, female Anopheles albimanus mosquito, Mahidol University, Francois Nosten, Shoklo Malaria Research Unit, artemisinin, malaria, medical research, Medical science, Mahidol University, World Health Organisation
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John Le Fevre

Deputy editor, Thailand & GMS editor at The Establishment Post

John Le Fevre is an Australian national with more than 35 years experience as a journalist, photographer, videographer and copy editor.

He is currently deputy editor and Thailand / GMS region editor for The Establishment Post

Opinions and views expressed on this site are those of the author’s only. Read more at About me

16 Responses to "Drug resistant malaria on Thailand-Burma border grows by 3,335%"

  1. chrisss   August 12, 2012 at 8:49 pm

    On the contrary! Global warming will see to that it spreads to New countries!
    And lawrence should obviously read what malaria actually is!
    It is a protozo, a plasmodium of 4 different types. This have been known for almost 200 years now, so its high time to wake up!;=))at least if you travel in malaria-infested areas.
    And there have been several drugs, but the plasmodium has the ability to develop imunity!

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  2. Lawrence Michaels   July 6, 2012 at 11:20 am

    This isn’t good news. I imagine that the virus can be spread even to those with vaccinations against the disease and not just those being treated after acquiring it.

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    • Daniel   July 22, 2012 at 4:24 am

      Whar are you talking about? 1. Malaria is NOT a viral desease, so there will be 2. NO vaccination against it! If this would be the case I am sure that there would be already a proper vaccibe against Malaria

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  3. Stephen   July 5, 2012 at 3:49 pm

    I do hope that there are steps taken to come up with a drug to cure this strain of malaria. If not, it will really pose a big problem in the near future.

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  4. John   June 13, 2012 at 3:17 pm

    This is one sad news. I wonder if there are measures being taken to make sure that the disease will not spread to other nations?

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  5. Megan   June 7, 2012 at 3:10 am

    Oh my, this is so alarming! I hope they find a cure to this, soon!

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  6. Peter   June 1, 2012 at 4:09 pm

    I hope that the authorities are doing something to solve this problem. It will really be bad if the disease carriers will go to other countries.

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  7. William   May 23, 2012 at 2:35 pm

    This is somewhat alarming! I guess there should be a check on the specie of the mosquitoes that carries the disease; better yet, a check on the sanitation on that border.

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  8. Andrew   May 11, 2012 at 6:51 pm

    I hope that this will not escalate into a bigger health problem.

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  9. Galen   May 2, 2012 at 3:30 pm

    This is alarming. I hope that there are measures to contain the disease.

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  10. adrian   April 29, 2012 at 10:57 am

    i shot this for Al jazeera almost 3 years ago at Francois Nosten’s clinic….. same story, same fears, clearly no progress made…

    http://vimeo.com/40437332

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    • John Le Fevre   April 29, 2012 at 12:39 pm

      Hello Adrian,

      Thanks very much for dropping by and posting the link to your video. Yes, it looks like nothing has improved.

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  11. Ruby   April 23, 2012 at 9:33 am

    The government need to ask help to the world health organization as well us other private pharmacological company for the drugs needed by this people. It is really alarming to have this number of casualties with this disease.

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  12. Gladys   April 20, 2012 at 3:48 pm

    This is not a great news to hear. Every year, almost hundreds of victims die due to Malaria and if there’ll be an increase in drug-resistant Malaria strains, it will be much harder to fight it. Let’s just hope that great scientist will try to make good antidote for this.

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  13. Michael   April 20, 2012 at 3:23 pm

    I wish that the drug companies will be quick enough to keep with the seemingly fast evolving disease carrier.

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  14. Nathan   April 10, 2012 at 3:59 pm

    It is so sad that there are already an increasing number of cases of drug resistant malaria. I hope that they will be able to find a new drug that can cure it. On the other hand, should we start calling for the use of DDT again?

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